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sunitinib + cisplatin + gemcitabine
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
A combination therapy consisting of sunitinib (a multitargeted tyrosine kinase inhibitor), cisplatin (a platinum-based chemotherapy agent), and gemcitabine (a nucleoside analog). This combination has been investigated in clinical trials for the treatment of advanced non-small cell lung cancer (NSCLC) and metastatic urothelial cancer (mUC). The regimen combines targeted therapy with conventional chemotherapy, targeting both angiogenesis pathways and cancer cell division.
- Brand names
- GemzarPlatinolSutent
- Other names
- gemcitabine hydrochloridecis-diamminedichloroplatinum(II)sunitinib malate
02
Targets
MET (Mesenchymal-epithelial transition factor receptor)KIT (c-KIT proto-oncogene receptor tyrosine kinase)VEGFR (VEGFR family)PDGFR (PDGFR family)RET (Rearranged during transfection receptor tyrosine kinase)FLT3 (Fms related receptor tyrosine kinase 3)
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