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surufatinib + penpulimab
- Development stage
- Unknown
- Lead developer
- HUTCHMED
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Surufatinib + penpulimab is a combination therapy consisting of surufatinib, a small molecule multi-kinase inhibitor, and penpulimab, a humanized IgG1 monoclonal antibody targeting the programmed cell death protein 1 (PD-1) receptor. Surufatinib inhibits vascular endothelial growth factor receptors (VEGFR 1/2/3), fibroblast growth factor receptor 1 (FGFR1), and colony-stimulating factor 1 receptor (CSF-1R), thereby inhibiting angiogenesis and modulating the tumor microenvironment by reducing tumor-associated macrophages. Penpulimab is a PD-1 inhibitor that restores T-cell mediated anti-tumor immune responses. This combination is being investigated for its synergistic potential in treating advanced solid tumors, including osteosarcoma and soft tissue sarcoma, where the anti-angiogenic and immunomodulatory effects of surufatinib may enhance the efficacy of PD-1 blockade.
- Other names
- surufatinib + penpulimab
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)VEGFR2 (Vascular endothelial growth factor receptor 2)FGFR3 (Fibroblast growth factor receptor 3)CSF1R (Macrophage colony-stimulating factor receptor)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR3 (Vascular endothelial growth factor receptor 3)FGFR2 (Keratinocyte growth factor receptor)FGFR1 (Fibroblast growth factor receptor 1)
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