Systane Nighttime Tears Again Ointment + miconazole nitrate + zinc oxide

This entity represents a combination of two ophthalmic lubricant brands, Systane Nighttime and Tears Again Ointment, with the antifungal agent miconazole nitrate and the skin protectant zinc oxide. Systane Nighttime and Tears Again Ointment are typically formulated with white petrolatum and mineral oil to provide an occlusive barrier that prevents moisture loss from the ocular surface, treating symptoms of dry eye. Miconazole nitrate is an imidazole antifungal that inhibits the synthesis of ergosterol by targeting the fungal enzyme lanosterol 14-alpha-demethylase, thereby disrupting cell membrane integrity. Zinc oxide serves as a mild astringent and topical barrier, commonly used to treat or prevent skin irritation. The inclusion of zinc oxide, which is generally not used in ophthalmic preparations due to potential irritation, suggests this combination may be a list of separate products or a specific compounded topical formulation rather than a standard commercial ophthalmic drug.

Brand names

Systane NighttimeTears Again Ointment

Other names

miconazole nitrate + zinc oxide + white petrolatum + mineral oil