Drug intelligence / Profile preview

T-cell infusion + influenza vaccine

Development stage
Preclinical
Lead developer
Novartis
Modality
Cell Therapies, Vaccines & Immunotherapeutics
Administration
Intravenous, Intramuscular
01

Overview

T-cell infusion + influenza vaccine is a combination immunotherapy approach that involves the adoptive transfer of T cells along with influenza vaccination. This strategy aims to enhance immune reconstitution and response to vaccines in patients undergoing treatments that compromise their immune system, such as autologous stem cell transplantation or CAR-T cell therapy. The T-cell infusion component typically involves collecting, potentially expanding, and reinfusing the patient's own T cells, while the influenza vaccine component consists of an inactivated influenza vaccine administered before and/or after the cell therapy procedure.

02

Targets

pMHC (Peptide-MHC complex family)

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