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Tartarase (Pontis Biologics, Inc.)

Development stage: Preclinical
Lead developer: Pontis Biologics
Administration: Topical

Overview

**Tartarase** is a proprietary topical enzyme dentifrice developed by Pontis Biologics for removal of pre-existing dental calculus. It contains digestive enzymes intended to locally degrade the organic matrix associated with mineralized tartar, facilitating calculus removal during brushing and tray-based oral application. Tartarase was evaluated in a completed 4-week randomized proof-of-principle clinical study in adults with dental calculus, compared with Crest toothpaste. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06139835))

Brand names: Tartarase

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