Drug intelligence / Profile preview

Td + Twinrix + Dukoral

Development stage: Unknown
Lead developer: Merck
Modality: Vaccines & Immunotherapeutics
Administration: Intramuscular, Oral

Overview

This vaccine regimen consists of three distinct vaccines: a Tetanus-Diphtheria (Td) toxoid vaccine (manufactured by Merck Sharp & Dohme), the Hepatitis A and Hepatitis B combination vaccine (Twinrix, manufactured by GSK), and an oral inactivated cholera vaccine (Dukoral, manufactured by Valneva). This specific combination was utilized in a Phase I clinical study (NCT03240133), titled "Predictor of Vaccine Hyporesponse in Healthy Elderly," to develop biomarker-based prediction rules for vaccine response in healthy elderly subjects. The regimen provides active immunization against *Clostridium tetani*, *Corynebacterium diphtheriae*, Hepatitis A virus, Hepatitis B virus, and *Vibrio cholerae*.

Brand names: TdTwinrixDukoral
Other names: tetanus toxoid + diphtheria toxoid-Merck Sharp & Dohme LLC-tetanus-diphtheria-hepatitis A-hepatitis B-choleraTetanus-Diphtheria-Hepatitis A-Hepatitis B-Cholera vaccine regimen

Targets

Diphtheria toxinHBsAg (Hepatitis B surface antigen)CTBS (Cholera toxin B subunit)Hepatitis A virus capsid proteinV. cholerae O1 LPS (Vibrio cholerae O1 lipopolysaccharide)

Beyond the preview

Go deeper on Td + Twinrix + Dukoral.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Td + Twinrix + Dukoral.

Explore the full profile