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technetium (99mtc) butedronic acid (CIS bio international)
- Development stage
- Unknown
- Lead developer
- Sanofi
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
Technetium (99mTc) butedronic acid, commonly known as technetium-99m dicarboxypropane diphosphonate (99mTc-DPD), is a diagnostic radiopharmaceutical used in nuclear medicine. It is a bone-seeking diphosphonate complex that selectively accumulates in the skeletal system by binding to hydroxyapatite crystals, particularly in areas of active bone remodeling and osteogenesis. Developed historically by Hoechst and Behringwerke, and currently marketed under the brand name Teceos by Curium, 99mTc-DPD is widely utilized for bone scintigraphy to detect skeletal metastases, fractures, and osteomyelitis. Additionally, it has emerged as a critical non-invasive diagnostic tool for identifying transthyretin amyloid cardiomyopathy (ATTR-CM) and differentiating it from light-chain amyloidosis (AL), as the tracer exhibits high affinity for amyloid-associated calcium deposits in the myocardium.
- Brand names
- Teceos
- Other names
- 99mTc-DPD99mTc-dicarboxypropane diphosphonatetechnetium (99mTc) butedronatetechnetium (99mTc) butedronic acidtechnetium Tc 99m 1,1-diphosphonopropane-2,3-dicarboxylic acidtechnetium Tc 99m butedronatetechnetium-99m butedronatetechnetium99m butedronatetechnetium 99m butedronatetechnetium-99m dicarboxypropane diphosphonatetechnetium99m dicarboxypropane diphosphonatetechnetium 99m dicarboxypropane diphosphonate
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