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technetium-99m nanocolloid + indocyanine green
- Development stage
- Preclinical
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Gamma Emitters → Radiopharmaceuticals
- Administration
- Intradermal, Subcutaneous
01
Overview
Technetium-99m nanocolloid + indocyanine green (also known as ICG-99mTc-nanocolloid) is a hybrid radioactive and fluorescent tracer designed for sentinel lymph node (SLN) mapping and biopsy. Developed through a collaboration between the Leiden University Medical Center (LUMC) and the Netherlands Cancer Institute (NKI-AVL), the tracer is prepared by mixing indocyanine green with human serum albumin-based technetium-99m nanocolloid, allowing the fluorescent dye to bind noncovalently to the radiocolloid. This dual-modality approach combines the deep-tissue penetration and preoperative imaging capabilities of the gamma-emitting technetium-99m isotope with the high-resolution, real-time visual guidance of near-infrared fluorescence from indocyanine green. It is widely investigated and clinically utilized to improve the accuracy of sentinel lymph node identification and surgical resection in various malignancies, including breast cancer, melanoma, penile cancer, vulvar cancer, and prostate cancer.
- Other names
- 99mTc-ICG-nanocolloid99mTc-nanocolloid-indocyanine greenICG-99mTc-nanocolloidICG99mTc-nanocolloidICG 99mTc-nanocolloidindocyanine green-99mTc-nanocolloidindocyanine green-technetium-99m-nanocolloidtechnetium-99m nanocolloid-indocyanine greentechnetium99m nanocolloid-indocyanine greentechnetium 99m nanocolloid-indocyanine green
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