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tegoprazan + atorvastatin
- Development stage
- Phase 1
- Lead developer
- HK inno.N Corporation
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
*tegoprazan + atorvastatin* is a **combination therapy** consisting of tegoprazan, a potassium-competitive acid blocker (P-CAB), and atorvastatin, a statin. Tegoprazan suppresses gastric acid secretion by competitively inhibiting potassium binding on gastric H,K-ATPase, while atorvastatin lowers blood cholesterol levels by inhibiting HMG-CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis. This combination is sometimes investigated for concurrent management of acid-related disorders and hyperlipidemia. Tegoprazan does not affect the pharmacokinetics of atorvastatin, unlike other P-CABs such as vonoprazan, which can increase systemic exposure of atorvastatin and risk of adverse effects by inhibiting CYP3A4[2][3][4]. Both agents are generally administered orally.
- Other names
- Tegoprazan/Atorvastatin FDC
02
Targets
HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)ATP4A (Potassium–transporting ATPase alpha chain 1)
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