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A combination of four nucleos(t)ide analogues used for treating chronic hepatitis B virus (HBV) infection. These medications work by inhibiting HBV DNA polymerase and reverse transcriptase, thereby suppressing viral replication. Each component has a distinct mechanism of action, and they are typically used in various combinations rather than all four simultaneously, with common pairings including lamivudine/telbivudine plus adefovir, or entecavir plus tenofovir for patients with lamivudine-resistant HBV.
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