Drug intelligence / Profile preview

telmisartan + rosuvastatin + ezetimibe

Development stage
Unknown
Lead developer
GC Biopharma
Modality
Small Molecules
Administration
Oral
01

Overview

**Rozetel** is an oral fixed-dose combination tablet developed and marketed by **GC Biopharma** for concurrent management of **hypertension** and **dyslipidemia**. Public clinical-trial and company materials identify it specifically as a three-drug polypill containing **telmisartan**, **rosuvastatin**, and **ezetimibe**. Its therapeutic rationale is complementary cardiovascular risk reduction: telmisartan blocks the angiotensin II type 1 receptor to lower blood pressure, rosuvastatin inhibits HMG-CoA reductase to reduce hepatic cholesterol synthesis and upregulate LDL receptor activity, and ezetimibe inhibits intestinal cholesterol absorption via NPC1L1. The product has been studied in real-world post-PCI patients for blood pressure and LDL-cholesterol control and is positioned for patients needing simultaneous antihypertensive and lipid-lowering therapy.

Brand names
Rozetel
Other names
telmisartan + rosuvastatin + ezetimibe
02

Targets

AGTR1 (Angiotensin II Type-1 receptor)NPC1L1 (Niemann-pick C1-Like 1 transporter)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

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