temozolomide + TACE

Temozolomide is an oral alkylating agent of the imidazotetrazine class used primarily to treat certain types of brain tumors such as glioblastoma multiforme and anaplastic astrocytoma[1][4][5][6]. It acts as a prodrug that undergoes rapid chemical conversion at physiological pH to its active metabolite MTIC (monomethyl triazeno imidazole carboxamide), which methylates DNA at the O6 position of guanine, leading to cytotoxicity by inhibiting DNA replication and cell division[2][4][6]. Transarterial chemoembolization (TACE) is not a drug but a locoregional interventional procedure commonly used for liver cancers; it involves delivering chemotherapy directly into the blood vessels feeding a tumor followed by embolization to block blood flow. The combination "temozolomide + TACE" refers to using temozolomide in conjunction with this procedure for synergistic anti-tumor effects in select clinical settings.

Other names

temozolomideTACE