Drug intelligence / Profile preview

terbutaline + metoprolol + carvedilol

Development stage
Preclinical
Lead developer
US Pharmaceutical Holdings I
Modality
Small Molecules
Administration
Oral, Inhalation, Subcutaneous, Intravenous
01

Overview

This is a combination of three distinct drugs with different mechanisms of action and clinical applications: - **Terbutaline**: A selective beta-2 adrenergic receptor agonist used to prevent bronchospasm in patients with asthma, bronchitis, emphysema, and other lung diseases. It works by relaxing the muscles in the bronchial tubes, increasing airflow through the lungs. - **Metoprolol**: A beta-1 selective beta-blocker that becomes progressively nonselective at higher doses. It's used to treat heart failure, hypertension, and other cardiovascular conditions. - **Carvedilol**: A non-selective beta-adrenergic antagonist that also has alpha-1 blocking properties. It's used to treat mild to severe chronic heart failure, hypertension, and left ventricular dysfunction following myocardial infarction. This combination is not a standard therapeutic regimen but has been studied in research contexts to understand drug interactions, particularly in patients who might require both bronchodilation and beta-blockade for coexisting conditions.

02

Targets

ADRB1 (β1)ADRB2 (β2)ADRA1A (α1A)

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