terconazole + clindamycin + fluocinolone acetonide

This is a **fixed-dose combination therapy** that includes **terconazole**, **clindamycin**, and **fluocinolone acetonide** delivered as a vaginal ovule[1][5]. - **Terconazole** is an antifungal that inhibits the synthesis of ergosterol, interfering with fungal cell membrane formation and function, stopping growth of the yeast[4][6]. - **Clindamycin** is a lincosamide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of susceptible bacteria, active against various gram-positive and anaerobic organisms[3]. - **Fluocinolone acetonide** is a synthetic corticosteroid with strong anti-inflammatory activity, acting mainly through glucocorticoid receptor agonism, leading to suppression of local inflammation[2]. The combination is under clinical investigation for the **treatment of vaginitis** (including mixed fungal and bacterial etiology) and **bacterial vaginosis**, aiming to address both bacterial and fungal components of vaginal infections as well as reduce associated inflammation[1][5].

Brand names

Gynoclin V

Other names

terconazole + clindamycin + fluocinolone acetonide