Drug intelligence / Profile preview

tertomotide + donepezil

Development stage
Preclinical
Lead developer
GemVax & Kael
Modality
Peptides, Small Molecules
Administration
Subcutaneous, Oral
01

Overview

**tertomotide + donepezil** is a combination of two drugs. *Tertomotide* is a peptide-based cancer vaccine studied primarily for its immunotherapeutic effects in some advanced cancers, such as pancreatic cancer, targeting tumor-associated antigens and stimulating T-cell responses. *Donepezil* is a small molecule acetylcholinesterase inhibitor, mainly approved for Alzheimer's disease, which works by increasing acetylcholine levels in the brain, leading to improvement in symptoms associated with cognitive impairment. There is no evidence of a marketed combination product or clinical trial listing for this exact combination; however, theoretically, the purpose would be to combine the immune modulation of tertomotide with the cognitive symptom improvements from donepezil[1][2][3][4][5].

Other names
tertomotide + donepezil
02

Targets

CYP3A4 (Cytochrome P450 3A4)CYP2D6 (Cytochrome P450 2D6)TERT (Telomerase)Acetylcholinesterase

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