testosterone (Havah Therapeutics)

Testosterone is a steroid hormone and androgen receptor agonist being developed by Havah Therapeutics as a subcutaneous implant. This specific formulation is under investigation in Phase II clinical trials to mitigate the side effects associated with aromatase inhibitor (AI) therapy in postmenopausal women with breast cancer. Specifically, it aims to reduce AI-induced arthralgia (joint pain) and prevent bone loss (osteoporosis) by activating androgen receptors, which play a role in musculoskeletal health and bone mineral density maintenance. The treatment is designed to provide sustained release of testosterone to improve quality of life and treatment adherence in breast cancer patients receiving background therapy such as anastrozole.

Other names

testosterone implantsubcutaneous testosterone implanttestosterone pellet