testosterone undecanoate + dutasteride

Testosterone undecanoate + dutasteride is a combination therapy consisting of an androgen (testosterone undecanoate) and a dual 5α-reductase inhibitor (dutasteride). Testosterone undecanoate is an ester prodrug of testosterone used for testosterone replacement therapy in adult males with primary or hypogonadotropic hypogonadism. It restores physiological levels of testosterone to treat symptoms related to deficiency such as reduced libido and muscle mass[4][5][7]. Dutasteride inhibits both type I and II 5α-reductase enzymes that convert testosterone into dihydrotestosterone (DHT), thereby reducing DHT-mediated effects like prostate enlargement[1]. The combination may be used experimentally or off-label to optimize androgen replacement while minimizing DHT-related side effects such as acne or benign prostatic hyperplasia. Dutasteride can also increase the oral bioavailability of testosterone by suppressing its conversion to DHT[3][5].

Brand names

KyzatrexTlandoUndecatrexAndriol

Other names

testosterone undecanoate + dutasterideTU + dutasteride