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Tetrakis(2-methoxyisobutylisonitrile)copper(I) tetrafluoroborate

Development stage: Approved
Lead developer: Lantheus
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

Tetrakis(2-methoxyisobutylisonitrile)copper(I) tetrafluoroborate is a coordination compound featuring a copper(I) center coordinated to four 2-methoxyisobutylisonitrile ligands. It is used as a component of the radiopharmaceutical agent Cardiolite, which is a technetium Tc99m-based imaging agent for assessing myocardial perfusion. The compound acts as a ligand precursor in the preparation of technetium Tc99m sestamibi, which accumulates in myocardial tissue and enables imaging of blood flow to detect coronary artery disease and localize myocardial ischemia[1][2][3][5].

Brand names: CardioliteCardio-Spect
Other names: tetrakis(2-methoxyisobutylisocyanide)copper(I) tetrafluoroboratecopper tetramibi tetrafluoroboratelambda1-copper(1+) tetrakis(1-isocyano-2-methoxy-2-methylpropane) tetrafluoroboranuide

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