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Thermella (Bonafide Health)
- Development stage
- Unknown
- Lead developer
- Bonafide Health
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Thermella is a non-hormonal, non-prescription botanical dietary supplement developed by Bonafide Health (a subsidiary of Pharmavite) for the management of menopausal vasomotor symptoms, such as hot flashes and night sweats. It is formulated as a proprietary blend of three key naturally derived ingredients: optimized curcumin extract, decaffeinated green tea extract, and spirulina extract. Thermella acts as a neurokinin 3 receptor (NK3R) antagonist, blocking the neurokinin B (NKB) pathway in the brain's thermoregulatory center (the hypothalamus) to restore temperature balance. This mechanism of action is similar to that of prescription NK3R antagonists like fezolinetant (Veozah), but Thermella offers a drug-free, over-the-counter alternative with rapid onset of action, typically showing efficacy within two weeks.
- Brand names
- Thermella
02
Targets
TACR3 (Neurokinin 3 Receptor)
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