Drug intelligence / Profile preview

thiamine + pyridoxine + cyanocobalamin + diclofenac + tizanidine

Development stage
Unknown
Lead developer
Novartis
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Oral
01

Overview

This is a fixed-dose **combination drug** of **thiamine**, **pyridoxine**, **cyanocobalamin**, **diclofenac**, and **tizanidine**. - **Diclofenac** is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase (COX) enzymes, blocking prostaglandin synthesis, thus reducing pain and inflammation[1][4][5]. - **Tizanidine** is a centrally acting skeletal muscle relaxant that is an agonist at α2-adrenergic receptors, reducing muscle tone by inhibiting spinal polysynaptic reflexes[1][4][5]. - **Thiamine (vitamin B1)**, **pyridoxine (vitamin B6)**, and **cyanocobalamin (vitamin B12)** are B group vitamins often included for their roles in nerve health and metabolism but have no direct analgesic or muscle relaxant effect; their addition is generally to support nerve health during the management of musculoskeletal pain and neuropathy. The primary indication for this combination is the **symptomatic treatment of musculoskeletal pain with associated muscle spasms**—such as acute low back pain, neck pain, joint pain, and spasticity. It also provides supportive micronutrients that may assist in nerve regeneration or recovery.

02

Targets

ADRA1A (α1A)ADRA2A (α2A)CD320 (Transcobalamin II receptor)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)HC (Haptocorrin)IR (Imidazoline receptor)THTR (Thiamine transporter 1)Pyridoxine transporterVitamin B12 transporter

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