Drug intelligence / Profile preview

thiocolchicoside + paracetamol

Development stage
Unknown
Lead developer
Libytec Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Thiocolchicoside + paracetamol is a fixed-dose combination small molecule drug used to treat acute pain associated with muscle spasms and various musculoskeletal conditions. Thiocolchicoside is a semi-synthetic derivative of colchicine that acts as a muscle relaxant by functioning as a GABA-A receptor agonist and glycine receptor antagonist in the central nervous system, thereby reducing muscle stiffness and spasms. Paracetamol (acetaminophen) is a widely used analgesic and antipyretic that works primarily by inhibiting prostaglandin synthesis in the central nervous system. This combination provides synergistic relief by addressing both the underlying muscle tension and the associated pain. It is typically administered orally in tablet or capsule form and is intended for short-term management of conditions such as low back pain, muscle strains, and post-surgical recovery.

Brand names
PathMuscleThioquest-PMyoril Plus
Other names
thiocolchicoside + acetaminophen
02

Targets

GABRR (GABA-A receptor subunit rho)Glycine receptorPTGS2 (Prostaglandin-Endoperoxide Synthase 2)GABRA2 (Gamma-aminobutyric acid receptor subunit alpha 2)

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