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Third Infectious diseases soup recipe + ribavirin
- Development stage
- Unknown
- Lead developer
- Guangzhou Eighth People's Hospital
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Third Infectious diseases soup recipe + ribavirin is an integrative combination therapy protocol developed by Guangzhou 8th People's Hospital for the treatment of various viral hemorrhagic fevers. This approach combines Traditional Chinese Medicine (TCM), specifically the 'Third Infectious diseases soup recipe' (a herbal decoction), with Western antiviral and supportive therapies, including ribavirin and hydrocortisone. Ribavirin serves as a broad-spectrum antiviral agent that inhibits viral RNA synthesis by targeting the viral RNA-directed RNA polymerase, while hydrocortisone is used as a glucocorticoid receptor agonist to manage inflammation. The TCM component is designed to address the 'syndrome of fever associated with bleeding' by modulating the host immune response and reducing clinical severity. This combination has been evaluated in Phase 2 clinical trials for indications such as dengue fever, hemorrhagic fever with renal syndrome (HFRS), and Crimean-Congo hemorrhagic fever.
- Other names
- TCM + Western MedicineThird Infectious diseases soup recipeChinese and Western Medicine Treatment of Fever Associated With Bleeding Symptoms
02
Targets
RdRp (Coronavirus RNA-dependent RNA polymerase)IMPDH (Inosine-5'-monophosphate dehydrogenase 1)
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