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thrombopoietin + interleukin-11 + heparin
- Development stage
- Preclinical
- Lead developer
- 3SBio
- Modality
- Recombinant Proteins and Enzymes, Small Molecules
- Administration
- Intravenous, Subcutaneous
01
Overview
A combination therapy consisting of thrombopoietin (TPO), interleukin-11 (IL-11), and heparin. This combination is primarily used to stimulate megakaryopoiesis and platelet production. Heparin significantly enhances the stimulating effects of TPO and IL-11 on megakaryocyte development and platelet production. The synergistic effect between heparin and IL-11 involves enhancement of IL-11-induced STAT3 activation through up-regulation of the MAPK pathway. This combination has been studied for the treatment of chemotherapy-induced thrombocytopenia and for ex vivo expansion of megakaryocyte progenitors.
02
Targets
TPOR (Thrombopoietin receptor)F10 (Factor Xa)ATIII (Antithrombin III)IL11RA (Interleukin-11 receptor subunit alpha)
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