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thymoglobulin + basiliximab + prednisolone

Development stage
Unknown
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Intravenous, Oral
01

Overview

This is a combination regimen used as induction and maintenance immunosuppression in solid organ transplantation, particularly kidney transplantation. The regimen typically includes: 1. **Thymoglobulin**: A polyclonal antibody that depletes T cells to prevent acute rejection. 2. **Basiliximab**: A monoclonal antibody targeting the interleukin 2 receptor alpha chain (CD25), blocking T cell activation. 3. **Prednisolone**: A synthetic glucocorticoid with broad anti-inflammatory and immunosuppressive effects. The combination is designed to provide potent early immunosuppression during the critical post-transplant period[1][2][3].

Brand names
DeltacortrilOrapredPediapred
Other names
Anti-thymocyte globulin + basiliximab + prednisone/prednisoloneATG+BAS+steroidrATG+BAS+steroid
02

Targets

IL2RA (Interleukin-2 receptor alpha subunit)CD3 (T-cell surface glycoprotein CD3)GR (Glucocorticoid receptor)

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