thymoglobulin + prednisone + mycophenolate sodium + tacrolimus

This is a combination immunosuppressive regimen commonly used for the prevention and treatment of acute rejection in kidney transplant recipients. The regimen includes: - **Thymoglobulin (anti-thymocyte globulin, rabbit):** A polyclonal antibody that depletes T lymphocytes by targeting multiple surface antigens, leading to profound immunosuppression. It is indicated for prophylaxis and treatment of acute rejection in kidney transplantation[1][2][3][4]. - **Prednisone:** A synthetic glucocorticoid corticosteroid that suppresses inflammation and immune responses by modulating gene expression. - **Mycophenolate sodium:** An inhibitor of inosine monophosphate dehydrogenase, which blocks purine synthesis required for lymphocyte proliferation. - **Tacrolimus:** A calcineurin inhibitor that suppresses T-cell activation by inhibiting the phosphatase activity of calcineurin, thereby reducing IL‑2 transcription[6]. Together, these agents act synergistically to prevent organ rejection after transplantation by targeting different pathways in the immune response.

Other names

anti-thymocyte globulin rabbitantithymocyte globulin rabbit