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timolol + brimonidine + dorzolamide + bimatoprost
- Development stage
- Phase 4
- Lead developer
- Harrow
- Modality
- Small Molecules
- Administration
- Ophthalmic
01
Overview
This quadruple-action topical ophthalmic formulation is used for the treatment of elevated intraocular pressure (IOP) in patients with open-angle glaucoma or ocular hypertension. It is typically prescribed when multi-drug therapy is required and aims to improve patient adherence by consolidating four medications into a single bottle. The combination integrates four distinct mechanisms: timolol (a non-selective beta-blocker) and dorzolamide (a carbonic anhydrase inhibitor) reduce aqueous humor production; brimonidine (an alpha-2 adrenergic agonist) reduces production while increasing uveoscleral outflow; and bimatoprost (a prostaglandin analog/prostamide) enhances both trabecular and uveoscleral drainage. By targeting multiple physiological pathways of aqueous humor dynamics, the formulation provides a potent synergistic effect on IOP reduction compared to monotherapy.
- Brand names
- Quad-ComboOMNI Quad
- Other names
- Tim-Brim-Dor-BimatTimolol/Brimonidine/Dorzolamide/BimatoprostQuadruple Combination Glaucoma Drops
02
Targets
ADRA2 (Adrenergic alpha-2 receptor family)PTGFR (Prostaglandin F2 alpha receptor)COM crystal surface (Calcium oxalate monohydrate crystal surface)ADRB1 (β1)
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