Drug intelligence / Profile preview

tirzepatide + mibavademab

Development stage
Phase 2
Lead developer
Eli Lilly
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Subcutaneous
01

Overview

This is a **combination of two investigational drugs: tirzepatide and mibavademab**, currently studied for obesity. Tirzepatide is a dual **glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide 1 (GLP-1) receptor agonist**, while mibavademab is an investigational monoclonal antibody. The main purpose of the combination is to assess whether adding mibavademab to tirzepatide can enhance weight loss in adults with obesity compared with tirzepatide alone. The combination is administered subcutaneously and is currently being evaluated in Phase 2 clinical trials[1][2][3][4][5][7].

Other names
tirzepatide + mibavademab
02

Targets

GIPR (Gastric inhibitory polypeptide receptor)GLP1R (GLP-1R)LEPR (Leptin receptor)

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