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tislelizumab + carboplatin + pemetrexed

Development stage: Unknown
Lead developer: BeiGene
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration: Intravenous

Overview

A combination therapy consisting of tislelizumab (an anti-PD-1 monoclonal antibody), carboplatin (a platinum-based chemotherapy), and pemetrexed (an antifolate antineoplastic agent). This regimen is primarily used for the treatment of advanced non-squamous non-small cell lung cancer (NSCLC). Tislelizumab is specifically engineered to minimize binding to FcγR on macrophages, which enhances its anti-tumor activity. In clinical trials, this combination has demonstrated significantly improved progression-free survival compared to chemotherapy alone.

Targets

GART (GAR transformylase)TS (Thymidylate synthase)DHFR (Dihydrofolate reductase)PDCD1 (Programmed cell death protein 1 receptor)DNA

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