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tislelizumab + regorafenib
- Development stage
- Unknown
- Lead developer
- BeiGene
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Tislelizumab + regorafenib is a combination therapy that pairs tislelizumab, a humanized monoclonal antibody directed against PD-1, with regorafenib, a multi-targeted tyrosine kinase inhibitor. This combination is being investigated primarily for the treatment of advanced hepatocellular carcinoma (HCC) and metastatic colorectal cancer (mCRC). The combination works by simultaneously blocking immune checkpoint inhibition (tislelizumab) and inhibiting multiple kinases involved in tumor angiogenesis and oncogenesis (regorafenib), potentially creating synergistic anti-tumor effects.
- Brand names
- StivargaTevimbra
- Other names
- regorafenib plus tislelizumab
02
Targets
CSF1R (Macrophage colony-stimulating factor receptor)BRAF (B-Raf proto-oncogene, serine/threonine kinase)KIT (c-KIT proto-oncogene receptor tyrosine kinase)VEGFR4 (Vascular endothelial growth factor Receptor-3)PDGFRB (Platelet-derived growth factor receptor beta)FGFR2 (Keratinocyte growth factor receptor)PDCD1 (Programmed cell death protein 1 receptor)TEK (Tie2)RAF1 (c-Raf-1 (Y340D/Y341D))RET (Rearranged during transfection receptor tyrosine kinase)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)FGFR1 (Fibroblast growth factor receptor 1)
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