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tobacco + nicotine
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Inhalation, Oral, Transdermal
01
Overview
Tobacco is a plant-derived product from the genus *Nicotiana* that contains nicotine, a potent parasympathomimetic alkaloid. Nicotine serves as the primary psychoactive and addictive component of tobacco, acting as an agonist at nicotinic acetylcholine receptors (nAChRs) throughout the central and peripheral nervous systems. In clinical and epidemiological research, "tobacco + nicotine" often refers to the exposure of individuals to tobacco products, which involves the inhalation or ingestion of nicotine alongside thousands of other chemical constituents. The provided context highlights a longitudinal study investigating the impact of prenatal tobacco exposure on children's brain development, specifically noting alterations in EEG power spectra and potential links to Attention Deficit Hyperactivity Disorder (ADHD) symptoms. While nicotine itself is used in pharmaceutical formulations for smoking cessation, tobacco is primarily a recreational substance with significant public health implications.
- Other names
- tobacconicotinecigarettestobacco smoke
02
Targets
Muscle-type nicotinic acetylcholine receptorα4β2 nAChR (Nicotinic acetylcholine receptor alpha4 beta2 subtype)α3α5β4 nAChR (α3α5β4 nicotinic receptor)CHRNA7 (α7 nicotinic receptor)α6β2 nAChR (α6β2 nicotinic receptor)
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