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tocopherol + pioglitazone
- Development stage
- Unknown
- Lead developer
- Takeda
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
tocopherol + pioglitazone is a combination therapy consisting of vitamin E (tocopherol), an antioxidant, and pioglitazone, a thiazolidinedione class insulin sensitizer. This combination has been studied primarily for the treatment of nonalcoholic steatohepatitis (NASH) and nonalcoholic fatty liver disease (NAFLD). Vitamin E acts as an antioxidant to reduce oxidative stress in hepatocytes, while pioglitazone is a peroxisome proliferator–activated receptor gamma (PPARγ) agonist that improves insulin sensitivity and modulates glucose and lipid metabolism. Clinical studies have shown that this combination produces greater improvements in liver histology—specifically reducing steatosis, cytologic ballooning, Mallory’s hyaline, and pericellular fibrosis—compared to vitamin E alone. The benefits are attributed to decreased fasting free fatty acids and insulin levels[1][2][7]. Pioglitazone also exerts anti-inflammatory effects through PPARγ activation[3][4].
- Other names
- vitamin E + pioglitazone
02
Targets
PPARG (Peroxisome proliferator-activated receptor gamma)
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