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topiramate + propranolol
- Development stage
- Unknown
- Lead developer
- Johnson & Johnson
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Topiramate is an antiepileptic drug used to prevent seizures and migraines. Its mechanism of action involves reducing neuronal hyperexcitability, likely through modulation of voltage-gated sodium channels, enhancement of GABA activity, antagonism at AMPA/kainate glutamate receptors, and inhibition of carbonic anhydrase. Propranolol is a non-selective beta blocker used for hypertension, arrhythmias, angina pectoris, essential tremor, migraine prevention, and anxiety. It works by blocking β-adrenergic receptors in the heart and other tissues. Both drugs are sometimes combined for migraine prevention when monotherapy is insufficient[1][3][4][5][6][8].
- Other names
- propranolol and topiramatepropranolol plus topiramate
02
Targets
iGluR (Ionotropic receptor 76b (Ir76b))ADRB1 (β1)ADRB2 (β2)CA2 (Carbonic Anhydrase 2)CA4 (Carbonic anhydrase 4)GABRR (GABA-A receptor subunit rho)GABA-B (Gamma-aminobutyric acid receptor type B)SCN1A (Voltage-gated sodium channel protein type 1 subunit alpha)
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