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toripalimab + fruquintinib + short-course radiotherapy
- Development stage
- Unknown
- Lead developer
- West China Hospital of Sichuan University
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
toripalimab + fruquintinib + short-course radiotherapy is a neoadjuvant combination therapy regimen being investigated for the treatment of locally advanced rectal cancer (LARC). The regimen consists of toripalimab, a humanized IgG4 monoclonal antibody targeting the programmed cell death protein 1 (PD-1) receptor; fruquintinib, a highly selective oral tyrosine kinase inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3; and short-course radiotherapy (SCRT). This combination aims to enhance anti-tumor activity through the synergistic effects of immune checkpoint blockade, inhibition of tumor angiogenesis, and radiation-induced immunogenic cell death. The regimen is currently being evaluated in a Phase II clinical trial led by West China Hospital of Sichuan University to assess its efficacy and safety in achieving pathological complete response in patients with LARC.
- Other names
- Fruquintinib combined with Toripalimab and SRT in Neoadjuvant Therapy for Locally Advanced Rectal Cancer
02
Targets
PDCD1 (Programmed cell death protein 1 receptor)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)VEGFR4 (Vascular endothelial growth factor Receptor-3)
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