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toripalimab + lenvatinib
- Development stage
- Unknown
- Lead developer
- Junshi Biosciences
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
Toripalimab + lenvatinib is a combination therapy that pairs a PD-1 inhibitor (toripalimab) with a multi-kinase inhibitor (lenvatinib). Toripalimab is a recombinant, humanized programmed cell death receptor-1 (PD-1) monoclonal antibody that blocks the interaction between PD-1 and its ligands, enhancing T-cell responses against tumor cells. Lenvatinib is a multi-kinase inhibitor that targets vascular endothelial growth factor receptors (VEGFR1-3), fibroblast growth factor receptors (FGFR1-4), platelet-derived growth factor receptor alpha (PDGFRα), KIT, and RET proto-oncogene. The combination aims to enhance antitumor activity through complementary mechanisms of immune checkpoint inhibition and anti-angiogenesis.
- Brand names
- TuoyiLenvima
- Other names
- Toripalimab plus Lenvatinib
02
Targets
FGFR4 (Fibroblast growth factor receptor 4)PDGFRA (Platelet-derived growth factor receptor alpha)KIT (c-KIT proto-oncogene receptor tyrosine kinase)PDCD1 (Programmed cell death protein 1 receptor)FGFR3 (Fibroblast growth factor receptor 3)VEGFR3 (Vascular endothelial growth factor receptor 3)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)FGFR1 (Fibroblast growth factor receptor 1)RET (Rearranged during transfection receptor tyrosine kinase)FGFR2 (Keratinocyte growth factor receptor)
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