TPP+C10

TPP+C10 is a research-stage small molecule compound derived from gallic acid, synthesized by conjugating gallic acid to a triphenylphosphonium (TPP+) cation via a 10-carbon (C10) alkyl chain linker. The lipophilic cation structure enables the compound to selectively accumulate in the mitochondrial matrix, driven by the mitochondrial membrane potential. Once inside, it uncouples the mitochondrial electron transport chain and disrupts organelle function, leading to a decay of transmembrane potential. TPP+C10 has demonstrated antifungal and antibiofilm activity against *Candida albicans* and has been investigated for anticancer activity in colorectal cancer (CRC) and non-small cell lung cancer (NSCLC). In cancer models, it shows antimigratory effects and activates AMPK metabolic signaling pathways. The compound was developed and studied by researchers at the University of Chile.

Other names

triphenylphosphonium-conjugated gallic acid C10 derivativeTPP-conjugated hydroxybenzoate