Drug intelligence / Profile preview

tralokinumab + topical corticosteroids

Development stage
Phase 4
Lead developer
LEO Pharma
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration
Subcutaneous, Topical
01

Overview

Tralokinumab + topical corticosteroids (TCS) is a combination therapy used for the treatment of moderate-to-severe atopic dermatitis (AD). Tralokinumab is a fully human monoclonal antibody that specifically neutralizes interleukin-13, a cytokine implicated as a key driver in the pathogenesis of AD. Topical corticosteroids are anti-inflammatory agents commonly used as first-line therapy for AD. The combination has been shown in multiple phase III clinical trials to be effective and well tolerated, providing early and sustained improvements in disease signs and symptoms compared to placebo plus TCS. This regimen is particularly relevant for patients whose disease is not adequately controlled with topical therapies alone or who have contraindications to systemic immunosuppressants[1][2][3][4][5][6].

Other names
tralokinumab + TCS
02

Targets

GR (Glucocorticoid receptor)IL-13 (Interleukin-13)IL13RA1 (Interleukin-13 receptor subunit alpha-1)

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