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tramadol + acetaminophen
- Development stage
- Phase 4
- Lead developer
- Daewon Pharm
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Wontran CR Tab is a fixed-dose combination of **tramadol hydrochloride**, a centrally acting opioid analgesic, and **acetaminophen** (paracetamol), a non-opioid analgesic and antipyretic. Developed by **Daewon Pharm**, it is formulated as a controlled-release tablet designed to provide sustained pain relief for moderate to severe acute and chronic pain. Tramadol exerts its effects as a mu-opioid receptor agonist and a weak inhibitor of norepinephrine and serotonin reuptake, while acetaminophen's mechanism primarily involves the inhibition of prostaglandin synthesis in the central nervous system. This combination leverages synergistic effects to improve analgesic efficacy while potentially reducing the required dose of the opioid component, thereby minimizing opioid-related side effects. The controlled-release formulation allows for less frequent dosing compared to immediate-release versions, improving patient compliance in chronic pain management.
- Brand names
- Wontran CR TabWontran CRWontran ER TabWontran
- Other names
- tramadol hydrochloride + acetaminophentramadol/acetaminophen CRtramadol/paracetamol ER
02
Targets
MOR (Mu opioid receptor)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)NET (Norepinephrine Transporter)SERT (Sodium-dependent serotonin transporter)
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