tramadol + paracetamol

Fornigesic is a branded generic combination analgesic marketed by Fornix Healthcare, an Indian pharmaceutical company. It is primarily formulated as a fixed-dose combination of tramadol hydrochloride (37.5 mg) and paracetamol (325 mg), although a single-ingredient tramadol injection is also available under the same brand name. Tramadol is a centrally acting synthetic opioid that provides analgesia through a dual mechanism: it acts as a weak agonist at the mu-opioid receptor and inhibits the neuronal reuptake of norepinephrine and serotonin, thereby enhancing descending inhibitory pain pathways. Paracetamol (acetaminophen) is a non-opioid analgesic and antipyretic that is thought to inhibit prostaglandin synthesis, particularly within the central nervous system. The combination of these two agents provides a synergistic effect, offering effective management for moderate to severe acute and chronic pain with a potentially improved safety profile compared to higher doses of single-agent opioids.

Brand names

Fornigesic

Other names

tramadol hydrochloride + paracetamoltramadol + acetaminophentramadol hydrochloride + acetaminophen