tramadol + paracetamol + diclofenac

The **Fix protocol** is a multimodal postoperative pain management regimen developed and evaluated by **HaEmek Medical Center** in Israel. Specifically designed for women recovering from Cesarean section, the protocol involves the scheduled (fixed-interval) administration of three distinct analgesic agents: **tramadol**, **paracetamol** (acetaminophen), and **diclofenac**. This combination targets multiple pain pathways by utilizing a mu-opioid receptor agonist (tramadol), a central analgesic (paracetamol), and a non-steroidal anti-inflammatory drug (diclofenac). The protocol aims to maintain steady therapeutic levels of these medications during the first 48 hours post-surgery to provide consistent pain control, improve patient satisfaction, and reduce the need for rescue doses compared to on-demand administration.

Other names

Fix protocolFixed-schedule pain relief protocolFix protocol-HaEmek Medical Center, Israel-postoperative pain