tranexamic acid + ethamsylate

Tranexamic acid + ethamsylate is a fixed-dose combination of two hemostatic agents used primarily to treat and prevent excessive bleeding, especially in conditions such as heavy menstrual bleeding and perioperative hemorrhage. Tranexamic acid is an antifibrinolytic that works by competitively inhibiting the activation of plasminogen to plasmin, thereby preventing the breakdown of fibrin clots and stabilizing blood clots[1][2][6]. Ethamsylate acts as a hemostatic by enhancing platelet adhesion and restoring capillary resistance, which helps control bleeding from small blood vessels (capillaries)[5]. The combination aims to provide synergistic effects for reducing blood loss in various clinical settings, including gynecological surgeries (e.g., myomectomy), obstetric hemorrhage (e.g., postpartum or post-caesarean section), and other surgical procedures[3][4][7]. Clinical studies suggest this combination can be effective in reducing intraoperative and postoperative blood loss without significant adverse effects[4][7].

Brand names

Sylate TEtosysTrapic ECosklot PlusClotawin-TTranlok ESyl PlusMenoguardMck E PlusEthasyl T

Other names

tranexamic acid + ethamsylate