TRAP-(FAPI)3

TRAP-(FAPI)3 is a trimeric radiopharmaceutical tracer designed for positron emission tomography (PET) imaging of malignant tumors. It specifically targets fibroblast activation protein (FAP), a cell-surface glycoprotein that is highly overexpressed on cancer-associated fibroblasts (CAFs) within the tumor microenvironment of more than 90% of epithelial cancers. The molecule is constructed using a TRAP (triazacyclononane-phosphinic acid) chelator scaffold conjugated to three FAPI (FAP inhibitor) subunits. This trimeric configuration is intended to exploit the multivalent effect, leading to increased binding affinity and significantly prolonged tumor retention compared to traditional monomeric FAPI analogs such as FAPI-04 or FAPI-46. By improving the pharmacokinetic profile and tumor-to-background ratio, TRAP-(FAPI)3 aims to enhance the sensitivity and specificity of non-invasive diagnosis, staging, and treatment monitoring across a wide range of solid tumors, including pancreatic, breast, and colorectal cancers.

Other names

TRAP-FAPi-trimertrimeric FAPI68Ga-TRAP-(FAPI)3TRAP-FAPi-3TRAP-FAPi3TRAP-FAPi 3