Drug intelligence / Profile preview

trappa ethanolamine + ciclosporin

Development stage
Unknown
Lead developer
Hengrui Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Trappa ethanolamine + ciclosporin is a **combination therapy** currently investigated for the treatment of non-severe aplastic anemia. Trappa ethanolamine is a mild sclerosing agent, while ciclosporin is an established immunosuppressant. The combination aims to leverage the immune-modulating properties of ciclosporin with the vascular and sclerosing actions of trappa ethanolamine. The primary mechanism is likely a synergy in immunosuppression (via ciclosporin's calcineurin inhibition) and hematopoietic support or modulation (potentially through ethanolamine’s vascular effects), though trappa ethanolamine’s specific hematological mechanism in this context is not fully established. This combination is the focus of clinical research, not yet established as an approved drug[1][3].

02

Targets

CN (Calcineurin)PPIA (Peptidyl-prolyl cis-trans isomerase A)

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