Drug intelligence / Profile preview

tretinoin + thioglycollate

Development stage
Unknown
Lead developer
Hainan Hospital of PLA General Hospital
Modality
Small Molecules
Administration
Topical
01

Overview

The name **tretinoin + thioglycollate** appears to be an erroneous transcription or misidentification of the combination of **triamcinolone acetonide and sucralfate**, as evidenced by the associated clinical trial registry ID **ChiCTR2200066181**. The actual study, sponsored by Hainan Hospital and Ruijin Hospital, evaluates the efficacy of a gel filling containing triamcinolone acetonide (a potent corticosteroid) and sucralfate (a mucosal protective agent) for the prevention of esophageal stricture following large-area endoscopic submucosal dissection (ESD). Triamcinolone acts by inhibiting the inflammatory response and reducing collagen synthesis to prevent fibrosis, while sucralfate provides a physical barrier over the injured esophageal mucosa to promote healing. Tretinoin is a retinoid typically used for acne or leukemia, and thioglycollate is a chemical reducing agent used in depilatories or culture media; neither is standardly used in this therapeutic context.

Other names
trimethoprim + thioglycollate
02

Targets

RARG (Retinoic acid receptor gamma)Protein disulfide bonds in keratin and extracellular matrix proteinsRARA (Retinoic acid receptor alpha)GR (Glucocorticoid receptor)RARB (Retinoic acid receptor beta)

Beyond the preview

Go deeper on tretinoin + thioglycollate.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Full profile access

Follow clinical development from study design and recruitment through results.

  • Trial phase
  • Status
  • Readouts

Indications & development

Full profile access

Explore development by indication, patient population, and geography.

  • Indications
  • Development status
  • Countries

Licensing & deals

Full profile access

Trace asset ownership, licensing agreements, and commercial partnerships.

  • Partners
  • Deal terms
  • Milestones

Patents & exclusivity

Full profile access

Explore the patent landscape and regulatory exclusivity around an asset.

  • Patents
  • Expiration dates
  • Exclusivity

Competitive landscape

Full profile access

Compare development programs by target, modality, and indication.

  • Competing assets
  • Targets
  • Development stage

Research & analysis

Full profile access

Connect source evidence and development news to your research questions.

  • Publications
  • News
  • Analysis

Bring the full picture into focus.

See how Gosset can support your research on tretinoin + thioglycollate.

Explore the full profile

Gosset Free

Get started with Gosset.

Enter your work email and we’ll be in touch with next steps.

Work email preferred.

Book a call