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triamcinolone + 5-fluorouracil
- Development stage
- Unknown
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Intralesional
01
Overview
Triamcinolone + 5-fluorouracil is a combination of two pharmaceutical agents used primarily as an intralesional injection for the treatment of keloids and hypertrophic scars. Triamcinolone acetonide is a synthetic glucocorticoid corticosteroid that reduces inflammation and suppresses fibroblast proliferation. 5-Fluorouracil is an antimetabolite chemotherapeutic agent that inhibits DNA synthesis by blocking thymidylate synthase, leading to reduced fibroblast activity and collagen production. The combination has demonstrated superior efficacy compared to corticosteroids alone in reducing scar size, improving appearance, lowering recurrence rates after excision, and decreasing relapse in chronic eczema with localized rash. The therapy is generally well tolerated; side effects are usually mild and localized[1][3][4][6].
- Brand names
- Kenalog
- Other names
- triamcinolone acetonide + 5-fluorouracilTAC + 5-FUTA + 5-FU
02
Targets
GR (Glucocorticoid receptor)TS (Thymidylate synthase)
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