Drug intelligence / Profile preview

triamcinolone + moxifloxacin

Development stage
Unknown
Lead developer
ImprimisRx
Modality
Small Molecules
Administration
Intraocular, Intravitreal, Ophthalmic
01

Overview

Triamcinolone + moxifloxacin is a fixed-dose combination of two active pharmaceutical ingredients: triamcinolone acetonide, a synthetic corticosteroid with potent anti-inflammatory properties, and moxifloxacin, a fourth-generation fluoroquinolone antibiotic. This combination is primarily administered via intraocular (intravitreal or transzonular) injection at the time of cataract surgery to control postoperative inflammation and prevent infection. The corticosteroid component (triamcinolone) acts by inhibiting multiple inflammatory cytokines and suppressing leukocyte infiltration, while the antibiotic component (moxifloxacin) inhibits bacterial DNA gyrase and topoisomerase IV, thereby preventing bacterial replication. The product is used as an alternative to topical eyedrop regimens for patients undergoing ocular surgery, especially those who may have difficulty adhering to postoperative drop schedules[1][6][8]. Some compounded formulations may include additional excipients such as poloxamer 407[2].

Brand names
Tri-Moxi+ PF
Other names
triamcinolone acetonide + moxifloxacinTriamcinolone-moxifloxacin ophthalmic preparation
02

Targets

GR (Glucocorticoid receptor)DNA gyraseTopo IV (Bacterial Topoisomerase IV)

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