Drug intelligence / Profile preview

triamcinolone acetonide + dimethicone

Development stage
Approved
Lead developer
Village Pharma
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Topical
01

Overview

**Triamcinolone acetonide + dimethicone** is a topical combination drug indicated for the relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses[1][5][7]. Triamcinolone acetonide is a synthetic fluorinated corticosteroid that reduces skin inflammation, itching, and redness by inhibiting phospholipase A2, thereby reducing synthesis of pro-inflammatory mediators[6][8]. Dimethicone is an emollient and skin protectant, used to moisturize, soothe, and protect the skin barrier. This combination product is applied as a cream or ointment to treat conditions including eczema, psoriasis, dermatitis, and other inflammatory skin disorders[7][8]. Triamcinolone acetonide acts as an agonist at the glucocorticoid receptor, leading to anti-inflammatory and immunosuppressive effects[6]. Dimethicone forms a protective barrier over the skin, reducing moisture loss and providing symptomatic relief.

Brand names
SCARZENTRIVIXELLZIA PAK
Other names
triamcinolone acetonide/dimethiconetriamcinolone acetonide + dimethicone kittriamcinolone acetonide cream + dimethicone cream
02

Targets

GR (Glucocorticoid receptor)

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