Drug intelligence / Profile preview

triamcinolone acetonide + indomethacin

Development stage
Unknown
Modality
Small Molecules
Administration
Intramuscular, Oral
01

Overview

This is a combination of triamcinolone acetonide, a corticosteroid, and indomethacin, a non-steroidal anti-inflammatory drug (NSAID). Triamcinolone acetonide is a synthetic glucocorticoid that prevents the release of substances in the body that cause inflammation. Indomethacin is an NSAID with anti-inflammatory, analgesic, and antipyretic properties that works by inhibiting the synthesis of prostaglandins. This combination is particularly used in the treatment of acute gout, with triamcinolone acetonide being as safe and effective as indomethacin alone. The combination is especially useful for patients who have contraindications to therapy with NSAIDs alone.

02

Targets

GR (Glucocorticoid receptor)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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