Drug intelligence / Profile preview

triamcinolone acetonide + miconazole + neomycin

Development stage
Unknown
Lead developer
Hubei Kangzheng Pharmaceutical
Modality
Small Molecules
Administration
Topical
01

Overview

This drug is a topical combination therapy developed by Hubei Kangzheng Pharmaceutical, containing triamcinolone acetonide, miconazole nitrate, and neomycin sulfate. It is specifically formulated for the treatment of mixed bacterial and fungal skin infections that are accompanied by significant inflammation. Triamcinolone acetonide is a potent synthetic corticosteroid that provides anti-inflammatory, antipruritic, and vasoconstrictive effects by activating glucocorticoid receptors. Miconazole is an imidazole antifungal agent that works by inhibiting the synthesis of ergosterol, thereby disrupting fungal cell membrane integrity. Neomycin is an aminoglycoside antibiotic that targets bacterial protein synthesis by binding to the 30S ribosomal subunit. This triple-action approach allows for the simultaneous management of infection and the symptomatic relief of associated skin irritation.

Brand names
复方曲安奈德/咪康唑/新霉素乳膏
Other names
Compound Triamcinolone Acetonide, Miconazole and Neomycin CreamTriamcinolone acetonide, miconazole nitrate and neomycin sulfate cream
02

Targets

GR (Glucocorticoid receptor)30S A-site (Bacterial ribosomal 30S A-site)CYP51A1 (Sterol 14α-demethylase)

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