tribenoside + lidocaine

**Tribenoside + lidocaine** is a fixed-dose topical and rectal small-molecule combination marketed as Procto-Glyvenol for symptomatic local treatment of internal and external hemorrhoids. Tribenoside is a vasoprotective agent with anti-inflammatory, anti-edema, antipruritic, and venotonic effects that may reduce capillary permeability and protect vascular endothelium, although its precise molecular target is not established. Lidocaine is an amide local anesthetic that reversibly blocks voltage-gated sodium channels in peripheral nerves, rapidly reducing hemorrhoid-associated pain, burning, and itching. The combination is supplied as rectal cream and suppositories and has been marketed by Novartis and subsequently acquired by Recordati in specified countries.

Other names

lidocaine + tribenosidelidocaine mixture with tribenosidetribenoside/lidocaine