triclosan + fluoride + metal salt

**triclosan + fluoride + metal salt** is a topical combination formulation used primarily in oral care products, such as toothpastes and mouthwashes, to prevent dental cavities, reduce dental plaque, and control gingivitis. Its canonical components are **triclosan** (an antimicrobial agent that kills micro-organisms primarily via inhibition of fatty acid synthesis by binding enoyl-acyl carrier protein reductase), **fluoride** (administered as sodium fluoride or sodium monofluorophosphate, promoting enamel resistance to acid and bacterial damage), and a **metal salt** (typically in the form of alumina or other metal-containing compounds, serving as an abrasive and/or stabilizer)[1][2][3][4].\nThe combination acts through three principal mechanisms: Triclosan inhibits microbial growth, fluoride strengthens enamel and inhibits caries, and the metal salt component (e.g., alumina) can reduce calculus formation while improving the abrasion profile of pastes. This combination is found in several marketed products for prevention of dental caries and management of oral biofilms.